ReShape Lifesciences™ Presents Information on Proprietary Diabetes Bloc-Stim Neuromodulation™ System at ObesityWeek® – StreetInsider.com
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Stimulation of Vagus Celiac Fibers with Concurrent Excessive Frequency Alternating Present Block of Hepatic Fibers Decreases Glucose Variability in a Swine Mannequin of Sort 2 Diabetes
SAN CLEMENTE, Calif., Nov. 03, 2022 (GLOBE NEWSWIRE) — ReShape Lifesciences™ (Nasdaq: RSLS), the premier physician-led weight reduction and metabolic well being options firm, immediately introduced the presentation of knowledge on its proprietary Diabetes Bloc-Stim Neuromodulation™ (DBSN™) machine in an summary on the Weight problems Society Annual Assembly, through the ObesityWeek® convention being held in San Diego, CA, November 1 – 4, 2022, with continued digital entry by December 31, 2022.
“Regardless of treatment, surgical procedure and weight loss program, sort 2 diabetes stays difficult to successfully deal with,” said Jonathan Waataja, Director of Analysis at ReShape Lifesciences. “Encouragingly, the corporate’s know-how has demonstrated each security and efficacy in a swine mannequin of sort 2 diabetes, displaying that bioelectronic modulation of nerves innervating organs that regulate plasma glucose (PG), using our proprietary DBSN™ machine, could also be a novel remedy choice for sort 2 diabetes.”
The summary reported is as follows:
Metabolic Results of Twin Neuromodulation of Vagus Nerve in a Sort 2 Diabetic Mannequin
ID: Poster-297
Session Title: Neuroscience
Monitor 2:
Authors: Raj Nihalani, M.D., Jonathan Waataja, Ph.D., Charles Billington, M.D.
Standalone stimulation of the vagus nerve, or vagotomy remedies, has blended or undesirable outcomes. Neuromodulation consisting of stimulation of celiac fibers innervating the pancreas with simultaneous reversible electrical blockade of neuronal hepatic fibers innervating the liver is a brand new therapeutic idea that that has been efficiently examined in animal fashions of sort 2 diabetes mellitus (T2DM). Beforehand, the world underneath the curve of oral glucose tolerance exams (OGTTs) was calculated to quantify glycemic management. Nevertheless, fluctuations in glucose through the OGTTs was not accessed. These fluctuations might have significance in treating T2DM, in that giant fluctuations in PG have been proven to extend oxidative stress and result in co-morbidities in T2DM. As a part of this research, these fluctuations had been studied throughout OGTTs in diabetic swine. Celiac fibers had been stimulated at a frequency of 1 Hz with concurrent software of excessive frequency alternating present (5000 Hz) blockade to hepatic fibers. Commonplace deviation (SD) and % coefficient of variation (%CV) had been used to quantify glycose variability through the OGTTs in an alloxan handled swine mannequin of sort 2 diabetes (n=3 w/ 3 OGTT). It was discovered that the DBSN™ considerably decreased SD and %CV in comparison with placebo.
“The chance to current such compelling information on our proprietary DBSN™ machine at this trade convention is a testomony to the market potential of the know-how to deal with sort 2 diabetes,” said Paul F. Hickey, President and Chief Government Officer of ReShape Lifesciences. “Backed by a powerful mental property portfolio, the DBSN™ machine has the potential to ship really personalised remedy by with the ability to regulate insulin manufacturing, as wanted, for any particular person. As beforehand reported, we’re using our second NIH SBIR grant to concentrate on the event of the know-how to deal with the metabolic dysfunction, hypoglycemia. We consider we’re on observe to additional the analysis of the DBSN™ machine to handle the numerous world diabetes market, by lowering sufferers’ dependence on drugs. As beforehand said, we proceed to finance the event of the DBSN™ although a non-dilutive funding technique and potential strategic alliances.”
About Diabetes Bloc-Stim Neuromodulation™ System
The Diabetes Bloc-Stim Neuromodulation™ (DBSN™) system is a novel therapeutic idea that’s implanted minimally invasively and delivers bio-electronic neuromodulation of vagus nerve branches which might be innervating organs which regulate plasma glucose. The DBSN™ system stimulates vagus celiac fibers of the pancreas to launch insulin throughout stimulation, whereas blocking the hepatic vagal department, innervating the liver, to lower glucose launch and reduce insulin resistance following ligation. The DBSN™ system makes use of a proprietary, reversable and adjustable electrical blockade felt to be key to the way forward for personalised medication. The DBSN™ system is superior to each standalone stimulation of the vagus nerve that has proven blended outcomes, and vagus nerve ligation that has undesirable results.
About ReShape Lifesciences™
ReShape Lifesciences™ is America’s premier weight reduction and metabolic health-solutions firm, providing an built-in portfolio of confirmed services and products that handle and deal with weight problems and metabolic illness. The FDA-approved Lap-Band® Program supplies minimally invasive, long-term remedy of weight problems and is a substitute for extra invasive surgical stapling procedures such because the gastric bypass or sleeve gastrectomy. Reshapecare™ is a digital weight-management program that helps life-style adjustments for all weight reduction sufferers led by board-certified well being coaches to assist them maintain the burden off over time. The lately launched ReShape Market™ is a web-based assortment of high quality wellness merchandise curated for all shoppers to assist them obtain their well being objectives. The investigational Diabetes Bloc-Stim Neuromodulation™ (DBSN™) system makes use of a proprietary vagus nerve block and stimulation know-how platform for the remedy of Sort 2 diabetes and metabolic issues. The Obalon® balloon know-how is a non-surgical, swallowable, gas-filled intra-gastric balloon that’s designed to supply long-lasting weight reduction. The ReShape Vest™ System is an investigational minimally invasive, laparoscopically implanted medical machine that wraps across the abdomen, emulating the gastric quantity discount impact of typical weight reduction surgical procedure. It helps allow fast weight reduction in individuals with weight problems with out completely altering affected person anatomy. For extra data, please go to www.reshapelifesciences.com.
Ahead-Trying Protected Harbor Assertion
This press launch might include forward-looking statements throughout the which means of the Personal Securities Litigation Reform Act of 1995. Precise outcomes might differ materially from these mentioned as a consequence of recognized and unknown dangers, uncertainties, and different components. These forward-looking statements usually could be recognized by means of phrases resembling “count on,” “plan,” “anticipate,” “might,” “might,” “intend,” “will,” “proceed,” “future,” different phrases of comparable which means and the usage of future dates. Ahead-looking statements on this press launch embody statements about our expectation that the advertising and marketing marketing campaign ought to proceed to advertise elevated demand for Lap-Band® procedures and, thus, doubtlessly a big improve in revenues for ReShape. These and extra dangers and uncertainties are described extra totally within the firm’s filings with the Securities and Change Fee, together with these components recognized as “threat components” in our most up-to-date Annual Report on Kind 10-Okay and subsequent Quarterly Studies on Kind 10-Q. We’re offering this data as of the date of this press launch and don’t undertake any obligation to replace any forward-looking statements contained on this doc on account of new data, future occasions or in any other case, besides as required by legislation.
CONTACTS
ReShape Lifesciences Investor Contact:
Thomas Stankovich
Chief Monetary Officer
949-276-6042
[email protected]
Investor Relations Contact:
Rx Communications Group
Michael Miller
(917)-633-6086
[email protected]
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